Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis

Tropane alkaloids such as hyoscyamine and cocaine are of importance in medicinal uses. Only recently has the hyoscyamine biosynthetic machinery become complete. However, the cocaine biosynthesis pathway remains only partially elucidated. Here we characterize polyketide synthases required for generat...

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Detalles Bibliográficos
Autores principales: Tian, Tian, Wang, Yong-Jiang, Huang, Jian-Ping, Li, Jie, Xu, Bingyan, Chen, Yin, Wang, Li, Yang, Jing, Yan, Yijun, Huang, Sheng-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411544/
https://www.ncbi.nlm.nih.gov/pubmed/36008484
http://dx.doi.org/10.1038/s41467-022-32776-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411544/
https://www.ncbi.nlm.nih.gov/pubmed/36008484
http://dx.doi.org/10.1038/s41467-022-32776-1

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