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Regulation of MMP9 transcription by ETS1 in immortalized salivary gland epithelial cells of patients with salivary hypofunction and primary Sjögren’s syndrome

Primary Sjögren’s syndrome (pSS) patients exhibit enhanced degradation of the salivary epithelium initially through MMP9 overexpression. We assessed the expression of MMP9 and an associated transcription factor, ETS1, in primary salivary gland epithelial cells (SGECs) and investigated potential regu...

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Detalles Bibliográficos
Autores principales: Noll, Braxton, Mougeot, Farah Bahrani, Brennan, Michael T., Mougeot, Jean-Luc C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411565/
https://www.ncbi.nlm.nih.gov/pubmed/36008454
http://dx.doi.org/10.1038/s41598-022-18576-z