The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence

Pseudomonas aeruginosa is intrinsically resistant to many antibiotics due to the impermeability of its outer membrane and to the constitutive expression of efflux pumps. Here, we show that the polyaminoisoprenyl compound NV716 at sub-MIC concentrations re-sensitizes P. aeruginosa to abandoned antibi...

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Detalles Bibliográficos
Autores principales: Wang, Gang, Brunel, Jean-Michel, Preusse, Matthias, Mozaheb, Negar, Willger, Sven D., Larrouy-Maumus, Gerald, Baatsen, Pieter, Häussler, Susanne, Bolla, Jean-Michel, Van Bambeke, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411590/
https://www.ncbi.nlm.nih.gov/pubmed/36008485
http://dx.doi.org/10.1038/s42003-022-03836-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411590/
https://www.ncbi.nlm.nih.gov/pubmed/36008485
http://dx.doi.org/10.1038/s42003-022-03836-5

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