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Deep blue autofluorescence reflects the oxidation state of human transthyretin

Human transthyretin (TTR) is a tetrameric protein transporting thyroid hormones and retinol. TTR is a neuroprotective factor and sensor of oxidative stress which stability is diminished due to mutations and aging, leading to amyloid deposition. Adverse environmental conditions, such as redox and met...

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Detalles Bibliográficos
Autores principales: Wieczorek, Elżbieta, Wygralak, Zofia, Kędracka-Krok, Sylwia, Bezara, Patrycja, Bystranowska, Dominika, Dobryszycki, Piotr, Ożyhar, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411673/
https://www.ncbi.nlm.nih.gov/pubmed/35987087
http://dx.doi.org/10.1016/j.redox.2022.102434