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The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people

Exosomes play an important role during human immunodeficiency virus (HIV) acute infection. Yet, information regarding its cargo and its association with HIV rapid progressors (RPs) and typical progressors (TPs) remain largely unknown. In this study, exosomal miRNAs sequencing and mass cytometry were...

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Autores principales: Li, Xin, Wang, Wenjing, Chen, Jing, Xie, Bangxiang, Luo, Shumin, Chen, Dexi, Cai, Chao, Li, Chuanyun, Li, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411714/
https://www.ncbi.nlm.nih.gov/pubmed/36032099
http://dx.doi.org/10.3389/fimmu.2022.939504
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author Li, Xin
Wang, Wenjing
Chen, Jing
Xie, Bangxiang
Luo, Shumin
Chen, Dexi
Cai, Chao
Li, Chuanyun
Li, Weihua
author_facet Li, Xin
Wang, Wenjing
Chen, Jing
Xie, Bangxiang
Luo, Shumin
Chen, Dexi
Cai, Chao
Li, Chuanyun
Li, Weihua
author_sort Li, Xin
collection PubMed
description Exosomes play an important role during human immunodeficiency virus (HIV) acute infection. Yet, information regarding its cargo and its association with HIV rapid progressors (RPs) and typical progressors (TPs) remain largely unknown. In this study, exosomal miRNAs sequencing and mass cytometry were used to identify differential exosomal miRNAs and membrane proteins that participate in the pathogenesis of TPs and RPs. We discovered that miR-144-5p, miR-1180-3p, miR-451a, miR-362-5p, and miR-625-5p are associated with the TPs and miR-362-5p with the RPs. Decreased autophagy, amino acid metabolism, immune response, and IL-6 are closely related to RPs. In addition, SP1 was selected as the most significant transcription factor (TF) associated with disease progression. CD49D, CD5, CCR5, CD40, CD14, and CD86 were selected as the differential exosomal membrane proteins between TPs and RPs. This study provides valuable information for clarifying the mechanism in people with acute HIV infection.
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spelling pubmed-94117142022-08-27 The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people Li, Xin Wang, Wenjing Chen, Jing Xie, Bangxiang Luo, Shumin Chen, Dexi Cai, Chao Li, Chuanyun Li, Weihua Front Immunol Immunology Exosomes play an important role during human immunodeficiency virus (HIV) acute infection. Yet, information regarding its cargo and its association with HIV rapid progressors (RPs) and typical progressors (TPs) remain largely unknown. In this study, exosomal miRNAs sequencing and mass cytometry were used to identify differential exosomal miRNAs and membrane proteins that participate in the pathogenesis of TPs and RPs. We discovered that miR-144-5p, miR-1180-3p, miR-451a, miR-362-5p, and miR-625-5p are associated with the TPs and miR-362-5p with the RPs. Decreased autophagy, amino acid metabolism, immune response, and IL-6 are closely related to RPs. In addition, SP1 was selected as the most significant transcription factor (TF) associated with disease progression. CD49D, CD5, CCR5, CD40, CD14, and CD86 were selected as the differential exosomal membrane proteins between TPs and RPs. This study provides valuable information for clarifying the mechanism in people with acute HIV infection. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411714/ /pubmed/36032099 http://dx.doi.org/10.3389/fimmu.2022.939504 Text en Copyright © 2022 Li, Wang, Chen, Xie, Luo, Chen, Cai, Li and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Xin
Wang, Wenjing
Chen, Jing
Xie, Bangxiang
Luo, Shumin
Chen, Dexi
Cai, Chao
Li, Chuanyun
Li, Weihua
The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
title The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
title_full The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
title_fullStr The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
title_full_unstemmed The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
title_short The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
title_sort potential role of exosomal mirnas and membrane proteins in acute hiv-infected people
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411714/
https://www.ncbi.nlm.nih.gov/pubmed/36032099
http://dx.doi.org/10.3389/fimmu.2022.939504
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