The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer

Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway h...

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Detalles Bibliográficos
Autores principales: Sabatini, Maria Elisa, Compagnoni, Micaela, Maffini, Fausto, Miccolo, Claudia, Pagni, Fabio, Lombardi, Mariano, Brambilla, Virginia, Lepanto, Daniela, Tagliabue, Marta, Ansarin, Mohssen, Citro, Simona, Chiocca, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411811/
https://www.ncbi.nlm.nih.gov/pubmed/36032664
http://dx.doi.org/10.3389/fmolb.2022.940449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411811/
https://www.ncbi.nlm.nih.gov/pubmed/36032664
http://dx.doi.org/10.3389/fmolb.2022.940449

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