The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer

Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway h...

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Autores principales: Sabatini, Maria Elisa, Compagnoni, Micaela, Maffini, Fausto, Miccolo, Claudia, Pagni, Fabio, Lombardi, Mariano, Brambilla, Virginia, Lepanto, Daniela, Tagliabue, Marta, Ansarin, Mohssen, Citro, Simona, Chiocca, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411811/
https://www.ncbi.nlm.nih.gov/pubmed/36032664
http://dx.doi.org/10.3389/fmolb.2022.940449
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author Sabatini, Maria Elisa
Compagnoni, Micaela
Maffini, Fausto
Miccolo, Claudia
Pagni, Fabio
Lombardi, Mariano
Brambilla, Virginia
Lepanto, Daniela
Tagliabue, Marta
Ansarin, Mohssen
Citro, Simona
Chiocca, Susanna
author_facet Sabatini, Maria Elisa
Compagnoni, Micaela
Maffini, Fausto
Miccolo, Claudia
Pagni, Fabio
Lombardi, Mariano
Brambilla, Virginia
Lepanto, Daniela
Tagliabue, Marta
Ansarin, Mohssen
Citro, Simona
Chiocca, Susanna
author_sort Sabatini, Maria Elisa
collection PubMed
description Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway has been also shown to be involved in the regulation of EMT in different cancers. Here we found an increased expression of UBC9 in the progression of Head and Neck Cancer (HNC) and uncovered a role for UBC9/SUMO in hampering the HPV-mediated E-cadherin cleavage in HNC.
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spelling pubmed-94118112022-08-27 The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer Sabatini, Maria Elisa Compagnoni, Micaela Maffini, Fausto Miccolo, Claudia Pagni, Fabio Lombardi, Mariano Brambilla, Virginia Lepanto, Daniela Tagliabue, Marta Ansarin, Mohssen Citro, Simona Chiocca, Susanna Front Mol Biosci Molecular Biosciences Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway has been also shown to be involved in the regulation of EMT in different cancers. Here we found an increased expression of UBC9 in the progression of Head and Neck Cancer (HNC) and uncovered a role for UBC9/SUMO in hampering the HPV-mediated E-cadherin cleavage in HNC. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411811/ /pubmed/36032664 http://dx.doi.org/10.3389/fmolb.2022.940449 Text en Copyright © 2022 Sabatini, Compagnoni, Maffini, Miccolo, Pagni, Lombardi, Brambilla, Lepanto, Tagliabue, Ansarin, Citro and Chiocca. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Sabatini, Maria Elisa
Compagnoni, Micaela
Maffini, Fausto
Miccolo, Claudia
Pagni, Fabio
Lombardi, Mariano
Brambilla, Virginia
Lepanto, Daniela
Tagliabue, Marta
Ansarin, Mohssen
Citro, Simona
Chiocca, Susanna
The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
title The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
title_full The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
title_fullStr The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
title_full_unstemmed The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
title_short The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
title_sort ubc9/sumo pathway affects e-cadherin cleavage in hpv-positive head and neck cancer
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411811/
https://www.ncbi.nlm.nih.gov/pubmed/36032664
http://dx.doi.org/10.3389/fmolb.2022.940449
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