Mathematical modelling of activation-induced heterogeneity in TNF, IL6, NOS2, and IL1β expression reveals cell state transitions underpinning macrophage responses to LPS

Background: Despite extensive work on macrophage heterogeneity, the mechanisms driving activation induced heterogeneity (AIH) in macrophages remain poorly understood. Here, we aimed to develop mathematical models to explore theoretical cellular states underpinning the empirically observed responses...

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Detalles Bibliográficos
Autores principales: Dey, Shoumit, Boucher, Dave, Pitchford, Jon, Lagos, Dimitris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411976/
https://www.ncbi.nlm.nih.gov/pubmed/36072059
http://dx.doi.org/10.12688/wellcomeopenres.17557.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411976/
https://www.ncbi.nlm.nih.gov/pubmed/36072059
http://dx.doi.org/10.12688/wellcomeopenres.17557.2

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