Cargando…

Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome

Women are disproportionately affected by Alzheimer's disease (AD), yet little is known about sex-specific effects on the development of AD in the Down syndrome (DS) population. DS is caused by a full or partial triplication of chromosome 21, which harbors the amyloid precursor protein (APP) gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andrews, Elizabeth J., Martini, Alessandra C., Head, Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411995/ https://www.ncbi.nlm.nih.gov/pubmed/36033603 http://dx.doi.org/10.3389/fnins.2022.954999

Ejemplares similares

Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis
por: Head, Elizabeth, et al.
Publicado: (2018)

Dissecting Alzheimer disease in Down syndrome using mouse models
por: Choong, Xun Yu, et al.
Publicado: (2015)

Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome
por: Martini, Alessandra C., et al.
Publicado: (2020)

Cerebrovascular pathology in Down syndrome and Alzheimer disease
por: Head, Elizabeth, et al.
Publicado: (2017)

Structural Connectivity in Down Syndrome and Alzheimer’s Disease
por: Saini, Fedal, et al.
Publicado: (2022)

Postmortem Neocortical (3)H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease
por: Pivtoraiko, Violetta N., et al.
Publicado: (2021)

Sex differences in risk of Alzheimer's disease in adults with Down syndrome
por: Lai, Florence, et al.
Publicado: (2020)

Con: are we ready to translate Alzheimer’s disease-modifying therapies to people with down syndrome?
por: Head, Elizabeth, et al.
Publicado: (2014)

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer’s disease biomarkers in down syndrome
por: Rafii, Michael S., et al.
Publicado: (2015)

Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome
por: Musaeus, Christian Sandøe, et al.
Publicado: (2019)

Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease
por: von Bernhardi, Rommy, et al.
Publicado: (2015)

The Eminent Role of microRNAs in the Pathogenesis of Alzheimer's Disease
por: Samadian, Mohammad, et al.
Publicado: (2021)

The role of sex differences in depression in pathologically defined Alzheimer’s disease
por: Tremblay, Cécilia, et al.
Publicado: (2023)

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease
por: Harris, Steven A., et al.
Publicado: (2018)

Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer’s Disease
por: Martinez, Jose L., et al.
Publicado: (2021)

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease
por: Chesser, Adrianne S., et al.
Publicado: (2013)

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease
por: Ohno, Masuo
Publicado: (2014)

The Role of Exosomes as Mediators of Neuroinflammation in the Pathogenesis and Treatment of Alzheimer’s Disease
por: Weng, Shiting, et al.
Publicado: (2022)

The Role of Iron-Induced Fibrin in the Pathogenesis of Alzheimer’s Disease and the Protective Role of Magnesium
por: Lipinski, Boguslaw, et al.
Publicado: (2013)

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses
por: Chen, Xu-Qiao, et al.
Publicado: (2019)

Can Control Infections Slow Down the Progression of Alzheimer’s Disease? Talking About the Role of Infections in Alzheimer’s Disease
por: Shi, Mingchao, et al.
Publicado: (2021)

Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease
por: Miguel, Jennifer C., et al.
Publicado: (2021)

Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer’s Disease
por: Lee, Ni-Chung, et al.
Publicado: (2017)

Corrigendum: Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer's Disease
por: Martinez, Jose L., et al.
Publicado: (2021)

Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches
por: Farrell, Clíona, et al.
Publicado: (2022)

Novel molecular mechanisms in Alzheimer’s disease: The potential role of DEK in disease pathogenesis
por: Greene, Allie N., et al.
Publicado: (2022)

Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease
por: Popugaeva, Elena, et al.
Publicado: (2013)

Astroglial and microglial pathology in Down syndrome: Focus on Alzheimer's disease
por: García, Octavio, et al.
Publicado: (2022)

Alzheimer’s disease like neuropathology in Down syndrome cortical organoids
por: Zhao, Helen H., et al.
Publicado: (2022)

Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer
por: Li, Xiaoshu, et al.
Publicado: (2021)

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease
por: Congdon, Erin E.
Publicado: (2018)

The Associations of Cerebrospinal Fluid ApoE and Biomarkers of Alzheimer’s Disease: Exploring Interactions With Sex
por: Liu, Ying, et al.
Publicado: (2021)

The Role of Chronic Inflammatory Bone and Joint Disorders in the Pathogenesis and Progression of Alzheimer's Disease
por: Culibrk, Robert A., et al.
Publicado: (2020)

A Dichotomous Role for FABP7 in Sleep and Alzheimer’s Disease Pathogenesis: A Hypothesis
por: Needham, Hope, et al.
Publicado: (2022)

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease
por: Lu, Xi, et al.
Publicado: (2015)

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
por: Wang, Xin, et al.
Publicado: (2017)

Role of miR-211 in Neuronal Differentiation and Viability: Implications to Pathogenesis of Alzheimer’s Disease
por: Fan, Chunying, et al.
Publicado: (2016)

The emerging role of autophagy and mitophagy in tauopathies: From pathogenesis to translational implications in Alzheimer’s disease
por: Liu, Xiaolan, et al.
Publicado: (2022)

The Association between Sex and Risk of Alzheimer’s Disease in Adults with Down Syndrome
por: Mhatre, Pooja Girish, et al.
Publicado: (2021)

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications
por: Liu, Jun-Lin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a4459rnpd0p44h90j9c1vi3qih