Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes

PF74 and 11L, as potent modulators of the HIV-1 capsid protein, have been demonstrated to act at both early and late stages in the HIV-1 life cycle. However, their clearance is high in human liver microsomes (HLMs). The main goal of this study was to clarify the metabolism of PF74 and 11L in HLMs, a...

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Detalles Bibliográficos
Autores principales: Xu, Shujing, Sun, Lin, Ding, Dang, Zhang, Xujie, Liu, Xinyong, Zhan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412436/
https://www.ncbi.nlm.nih.gov/pubmed/36005624
http://dx.doi.org/10.3390/metabo12080752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412436/
https://www.ncbi.nlm.nih.gov/pubmed/36005624
http://dx.doi.org/10.3390/metabo12080752

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