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Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes
PF74 and 11L, as potent modulators of the HIV-1 capsid protein, have been demonstrated to act at both early and late stages in the HIV-1 life cycle. However, their clearance is high in human liver microsomes (HLMs). The main goal of this study was to clarify the metabolism of PF74 and 11L in HLMs, a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412436/ https://www.ncbi.nlm.nih.gov/pubmed/36005624 http://dx.doi.org/10.3390/metabo12080752 |