Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation

The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyze...

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Detalles Bibliográficos
Autor principal: Potęga, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412641/
https://www.ncbi.nlm.nih.gov/pubmed/36014491
http://dx.doi.org/10.3390/molecules27165252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412641/
https://www.ncbi.nlm.nih.gov/pubmed/36014491
http://dx.doi.org/10.3390/molecules27165252

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