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Synthesis of the extracellular domain of GLP-1R by chemical and biotechnological approaches

The extracellular domain of the glucagon-like peptide-1 receptor, GLP-1R, is responsible for the binding of GLP-1, and a handful of additional agonists (such as exenatide, lixisenatide, and liraglutide) used daily for treating type II diabetes mellitus. Lead discovery and optimization, however, requ...

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Detalles Bibliográficos
Autores principales: Szolomajer, János, Stráner, Pál, Kele, Zoltán, Tóth, Gábor K., Perczel, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412715/
https://www.ncbi.nlm.nih.gov/pubmed/36128537
http://dx.doi.org/10.1039/d2ra02784d