The Potential of Topoisomerase Inhibitor-Based Antibody–Drug Conjugates

DNA topoisomerases are essential enzymes that stabilize DNA supercoiling and resolve entanglements. Topoisomerase inhibitors have been widely used as anti-cancer drugs for the past 20 years. Due to their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage complexes, camptothecin...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Seungmin, Lim, Kwang Suk, Blackburn, Brody J., Yun, Jina, Putnam, Charles W., Bull, David A., Won, Young-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413092/
https://www.ncbi.nlm.nih.gov/pubmed/36015333
http://dx.doi.org/10.3390/pharmaceutics14081707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413092/
https://www.ncbi.nlm.nih.gov/pubmed/36015333
http://dx.doi.org/10.3390/pharmaceutics14081707

Ejemplares similares