Spatially resolved proteomic profiling identifies tumor cell CD44 as a biomarker associated with sensitivity to PD-1 axis blockade in advanced non-small-cell lung cancer

BACKGROUND: Most patients with advanced non-small-cell lung cancer (NSCLC) fail to derive significant benefit from programmed cell death protein-1 (PD-1) axis blockade, and new biomarkers of response are needed. In this study, we aimed to discover and validate spatially resolved protein markers asso...

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Detalles Bibliográficos
Autores principales: Moutafi, Myrto K, Molero, Magdalena, Martinez Morilla, Sandra, Baena, Javier, Vathiotis, Ioannis A, Gavrielatou, Niki, Castro-Labrador, Laura, de Garibay, Gorka Ruiz, Adradas, Vera, Orive, Daniel, Valencia, Karmele, Calvo, Alfonso, Montuenga, Luis M, Ponce Aix, S, Schalper, Kurt A, Herbst, Roy S, Paz-Ares, Luis, Rimm, David L, Zugazagoitia, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413286/
https://www.ncbi.nlm.nih.gov/pubmed/36002182
http://dx.doi.org/10.1136/jitc-2022-004757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413286/
https://www.ncbi.nlm.nih.gov/pubmed/36002182
http://dx.doi.org/10.1136/jitc-2022-004757

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