Cargando…

Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain

Although opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common drugs used in persistent pain treatment; they have shown many side effects. The development of new analgesics endowed with mu opioid receptor/delta opioid receptor (MOR/DOR) activity represents a promising alterna...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turnaturi, Rita, Chiechio, Santina, Pasquinucci, Lorella, Spoto, Salvatore, Costanzo, Giuliana, Dichiara, Maria, Piana, Silvia, Grasso, Margherita, Amata, Emanuele, Marrazzo, Agostino, Parenti, Carmela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413390/ https://www.ncbi.nlm.nih.gov/pubmed/36014375 http://dx.doi.org/10.3390/molecules27165135

Ejemplares similares

New Insights into the Opioid Analgesic Profile of cis-(−)-N-Normetazocine-derived Ligands
por: Costanzo, Giuliana, et al.
Publicado: (2023)

Synthesis and Structure-Activity Relationships of (−)-cis-N-Normetazocine-Based LP1 Derivatives
por: Pasquinucci, Lorella, et al.
Publicado: (2018)

The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling
por: Fidilio, Annamaria, et al.
Publicado: (2021)

From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design
por: Turnaturi, Rita, et al.
Publicado: (2023)

Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles
por: Montenegro, Lucia, et al.
Publicado: (2017)

Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands
por: Dichiara, Maria, et al.
Publicado: (2023)

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists
por: Turnaturi, Rita, et al.
Publicado: (2018)

Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain
por: Vicario, Nunzio, et al.
Publicado: (2022)

Sigma-2 receptor ligands QSAR model dataset
por: Rescifina, Antonio, et al.
Publicado: (2017)

In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations
por: Montenegro, Lucia, et al.
Publicado: (2018)

Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect
por: Montenegro, Lucia, et al.
Publicado: (2017)

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy
por: Montenegro, Lucia, et al.
Publicado: (2018)

Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
por: Dichiara, Maria, et al.
Publicado: (2023)

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands
por: Floresta, Giuseppe, et al.
Publicado: (2019)

LP1 and LP2: Dual-Target MOPr/DOPr Ligands as Drug Candidates for Persistent Pain Relief
por: Pasquinucci, Lorella, et al.
Publicado: (2021)

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opioid receptors-mediated antiallodinic effect
por: Vicario, Nunzio, et al.
Publicado: (2016)

A Structure- and Ligand-Based Virtual Screening of a Database of “Small” Marine Natural Products for the Identification of “Blue” Sigma-2 Receptor Ligands
por: Floresta, Giuseppe, et al.
Publicado: (2018)

Haloperidol Metabolite II Valproate Ester (S)-(−)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma
por: Barbaraci, Carla, et al.
Publicado: (2021)

Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity
por: De Luca, Laura, et al.
Publicado: (2023)

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands
por: Zampieri, Daniele, et al.
Publicado: (2023)

Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents
por: Fallica, Antonino Nicolò, et al.
Publicado: (2021)

Correction to “Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents”
por: Fallica, Antonino Nicolò, et al.
Publicado: (2022)

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice
por: Zammataro, Magda, et al.
Publicado: (2017)

Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H(3) and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
por: Szczepańska, Katarzyna, et al.
Publicado: (2021)

Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats
por: Parenti, Carmela, et al.
Publicado: (2015)

HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors
por: Zammataro, Magda, et al.
Publicado: (2014)

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands
por: Nastasi, Giovanni, et al.
Publicado: (2017)

Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
por: Longhitano, Lucia, et al.
Publicado: (2017)

Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors
por: Amata, Emanuele, et al.
Publicado: (2017)

Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization
por: Puglia, Carmelo, et al.
Publicado: (2020)

Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity
por: Romeo, Giuseppe, et al.
Publicado: (2021)

Dual Piperidine-Based Histamine H(3) and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
por: Szczepańska, Katarzyna, et al.
Publicado: (2023)

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
por: Zammataro, Magda, et al.
Publicado: (2011)

Exploring the Role of Hsp60 in Alzheimer’s Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting
por: Zimbone, Stefania, et al.
Publicado: (2023)

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-κB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine
por: Chiechio, Santina, et al.
Publicado: (2006)

l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug
por: Chiechio, Santina, et al.
Publicado: (2017)

A Standardized Extract Prepared from Red Orange and Lemon Wastes Blocks High-Fat Diet-Induced Hyperglycemia and Hyperlipidemia in Mice
por: Chiechio, Santina, et al.
Publicado: (2021)

Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective
por: Fallica, Antonino N., et al.
Publicado: (2021)

Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products
por: Floresta, Giuseppe, et al.
Publicado: (2019)

A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach
por: Floresta, Giuseppe, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vovaj6mrq6vaf2den2f80oumsu