Signature Effects of Vector-Guided Systemic Nano Bioconjugate Delivery Across Blood-Brain Barrier of Normal, Alzheimer’s, and Tumor Mouse Models

[Image: see text] The ability to cross the blood-brain barrier (BBB) is critical for targeted therapy of the central nerve system (CNS). Six peptide vectors were covalently attached to a 50 kDa poly(β-l-malic acid)-trileucine polymer forming P/LLL(40%)/vector conjugates. The vectors were Angiopep-2...

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Detalles Bibliográficos
Autores principales: Israel, Liron L., Galstyan, Anna, Cox, Alysia, Shatalova, Ekaterina S., Sun, Tao, Rashid, Mohammad-Harun, Grodzinski, Zachary, Chiechi, Antonella, Fuchs, Dieu-Trang, Patil, Rameshwar, Koronyo-Hamaoui, Maya, Black, Keith L., Ljubimova, Julia Y., Holler, Eggehard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413444/
https://www.ncbi.nlm.nih.gov/pubmed/35961653
http://dx.doi.org/10.1021/acsnano.1c10034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413444/
https://www.ncbi.nlm.nih.gov/pubmed/35961653
http://dx.doi.org/10.1021/acsnano.1c10034

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