PI3K/mTOR Dual Inhibitor Pictilisib Stably Binds to Site I of Human Serum Albumin as Observed by Computer Simulation, Multispectroscopic, and Microscopic Studies

Pictilisib (GDC-0941) is a well-known dual inhibitor of class I PI3K and mTOR and is presently undergoing phase 2 clinical trials for cancer treatment. The present work investigated the dynamic behaviors and interaction mechanism between GDC-0941 and human serum albumin (HSA). Molecular docking and...

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Detalles Bibliográficos
Autores principales: Yang, Hongqin, Ma, Yanjun, Zhang, Hongjie, Ma, Junyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413508/
https://www.ncbi.nlm.nih.gov/pubmed/36014303
http://dx.doi.org/10.3390/molecules27165071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413508/
https://www.ncbi.nlm.nih.gov/pubmed/36014303
http://dx.doi.org/10.3390/molecules27165071

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