Computational analysis of 4-1BB-induced NFκB signaling suggests improvements to CAR cell design

BACKGROUND: Chimeric antigen receptor (CAR)-expressing cells are a powerful modality of adoptive cell therapy against cancer. The potency of signaling events initiated upon antigen binding depends on the costimulatory domain within the structure of the CAR. One such costimulatory domain is 4-1BB, wh...

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Detalles Bibliográficos
Autores principales: Tserunyan, Vardges, Finley, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413922/
https://www.ncbi.nlm.nih.gov/pubmed/36028884
http://dx.doi.org/10.1186/s12964-022-00937-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413922/
https://www.ncbi.nlm.nih.gov/pubmed/36028884
http://dx.doi.org/10.1186/s12964-022-00937-w

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