Cargando…

Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy

Pharmaceutical proteins, compared to small molecular weight drugs, are relatively fragile molecules, thus necessitating monitoring protein unfolding and aggregation during production and post-marketing. Currently, many analytical techniques take offline measurements, which cannot directly assess pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Itkonen, Jaakko, Ghemtio, Leo, Pellegrino, Daniela, Jokela (née Heinonen), Pia J., Xhaard, Henri, Casteleijn, Marco G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413954/ https://www.ncbi.nlm.nih.gov/pubmed/36015265 http://dx.doi.org/10.3390/pharmaceutics14081639

Ejemplares similares

Assessment of recombinant protein production in E. coli with Time-Gated Surface Enhanced Raman Spectroscopy (TG-SERS)
por: Kögler, Martin, et al.
Publicado: (2020)

Predictive classification models and targets identification for betulin derivatives as Leishmania donovani inhibitors
por: Zhang, Yuezhou, et al.
Publicado: (2018)

IDAAPM: integrated database of ADMET and adverse effects of predictive modeling based on FDA approved drug data
por: Legehar, Ashenafi, et al.
Publicado: (2016)

Fast Gating for Raman Spectroscopy
por: Chiuri, Andrea, et al.
Publicado: (2021)

Binding Site Interactions of Modulators of Breast Cancer Resistance Protein, Multidrug Resistance-Associated Protein 2, and P-Glycoprotein Activity
por: Deng, Feng, et al.
Publicado: (2020)

Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug
por: del Amo, Eva M., et al.
Publicado: (2013)

Correction: Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug
por: del Amo, Eva M., et al.
Publicado: (2015)

Operando time-gated Raman spectroscopy of solid catalysts
por: Vogel, Robin, et al.
Publicado: (2023)

Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation
por: Richardson, Dominique, et al.
Publicado: (2018)

Raman Spectroscopy for Chemical Biology Research
por: Dodo, Kosuke, et al.
Publicado: (2022)

Challenges in application of Raman spectroscopy to biology and materials
por: Kuhar, Nikki, et al.
Publicado: (2018)

Atmospheric oxidation and carbon contamination of silver and its effect on surface-enhanced Raman spectroscopy (SERS)
por: Matikainen, Antti, et al.
Publicado: (2016)

KNeMAP: a network mapping approach for knowledge-driven comparison of transcriptomic profiles
por: Pavel, Alisa, et al.
Publicado: (2023)

Towards the in vivo prediction of fragility fractures with Raman spectroscopy
por: Buckley, Kevin, et al.
Publicado: (2015)

Time-Gated Raman Spectroscopy for Quantitative Determination of Solid-State Forms of Fluorescent Pharmaceuticals
por: Lipiäinen, Tiina, et al.
Publicado: (2018)

Waveguiding and SERS Simplified Raman Spectroscopy on Biological Samples
por: Valpapuram, Immanuel, et al.
Publicado: (2019)

Raman spectroscopy
por: Bhattacharjee, Tanmoy
Publicado: (2015)

Time-gated Raman spectroscopy and proteomics analyses of hypoxic and normoxic renal carcinoma extracellular vesicles
por: Samoylenko, Anatoliy, et al.
Publicado: (2021)

Towards refining Raman spectroscopy-based assessment of bone composition
por: Shah, Furqan A.
Publicado: (2020)

Optimization of Nanosubstrates toward Molecularly Surface-Functionalized Raman Spectroscopy
por: De Carvalho Gomes, Paulo, et al.
Publicado: (2022)

Raman Spectroscopy of Optically Trapped Single Biological Micro-Particles
por: Redding, Brandon, et al.
Publicado: (2015)

Sensitivity of Transmission Raman Spectroscopy Signals to Temperature of Biological Tissues
por: Ghita, Adrian, et al.
Publicado: (2018)

Raman Spectroscopy and Its Modifications Applied to Biological and Medical Research
por: Allakhverdiev, Elvin S., et al.
Publicado: (2022)

Special Issue on “Raman Spectroscopy for Chemical and Structural Characterization in Biology”
por: Bonhommeau, Sébastien
Publicado: (2022)

Systems Biological Approach of Molecular Descriptors Connectivity: Optimal Descriptors for Oral Bioavailability Prediction
por: Ahmed, Shiek S. S. J., et al.
Publicado: (2012)

Practical raman spectroscopy
por: Gardiner, Derek J, et al.
Publicado: (1989)

Coherent Raman spectroscopy
por: Eesley, G L
Publicado: (1981)

Introductory Raman spectroscopy
por: Ferraro, John R., 1918-
Publicado: (1994)

Introductory Raman Spectroscopy
por: Ferraro, John R, et al.
Publicado: (2002)

Introductory Raman spectroscopy
por: Ferraro, John R, et al.
Publicado: (2012)

Raman spectroscopy for medulloblastoma
por: Polis, Bartosz, et al.
Publicado: (2018)

Towards early dental caries detection with OCT and polarized Raman spectroscopy
por: Choo-Smith, Lin-P'ing, et al.
Publicado: (2010)

Towards ultrasensitive malaria diagnosis using surface enhanced Raman spectroscopy
por: Chen, Keren, et al.
Publicado: (2016)

Towards Fingermark Dating: A Raman Spectroscopy Proof‐of‐Concept Study
por: Andersson, Per Ola, et al.
Publicado: (2017)

Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models
por: Itkonen, Jaakko, et al.
Publicado: (2020)

Rise of Raman spectroscopy in neurosurgery: a review
por: DePaoli, Damon, et al.
Publicado: (2020)

Atomic Force Microscopy Based Tip-Enhanced Raman Spectroscopy in Biology
por: Gao, Lizhen, et al.
Publicado: (2018)

Raman Spectroscopy Technique: A Non-Invasive Tool in Celiac Disease Diagnosis
por: Acri, Giuseppe, et al.
Publicado: (2021)

Fast Detection of Different Water Contaminants by Raman Spectroscopy and Surface-Enhanced Raman Spectroscopy
por: Almaviva, Salvatore, et al.
Publicado: (2022)

Surface-enhanced Raman spectroscopy of tears: toward a diagnostic tool for neurodegenerative disease identification
por: Cennamo, Gilda, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9k970qe8lc1gm9h1eprbc06gp2