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pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells

The blood–brain barrier (BBB), which is comprised of brain capillary endothelial cells, plays a pivotal role in the transport of drugs from the blood to the brain. Therefore, an analysis of proteins in the endothelial cells, such as transporters and tight junction proteins, which contribute to BBB f...

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Detalles Bibliográficos
Autores principales: Sakurai, Yu, Watanabe, Himeka, Nishio, Kazuma, Hashimoto, Kohei, Harada, Atsuki, Gomi, Masaki, Suzuki, Masayoshi, Oyama, Ryotaro, Handa, Takumi, Sato, Risa, Takeuchi, Hina, Taira, Ryoga, Tezuka, Kenta, Tange, Kota, Nakai, Yuta, Akita, Hidetaka, Uchida, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413996/
https://www.ncbi.nlm.nih.gov/pubmed/36015185
http://dx.doi.org/10.3390/pharmaceutics14081560