Cargando…

Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice

Parkinson’s disease (PD) is characterized by dopaminergic nigrostriatal neurons degeneration and Lewy body pathology, mainly composed of α-synuclein (αSyn) fibrillary aggregates. We recently described that the neuronal phosphoprotein Synapsin III (Syn III) participates in αSyn pathology in PD brains...

Descripción completa

Detalles Bibliográficos
Autores principales:	Casiraghi, Andrea, Longhena, Francesca, Faustini, Gaia, Ribaudo, Giovanni, Suigo, Lorenzo, Camacho-Hernandez, Gisela Andrea, Bono, Federica, Brembati, Viviana, Newman, Amy Hauck, Gianoncelli, Alessandra, Straniero, Valentina, Bellucci, Arianna, Valoti, Ermanno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414221/ https://www.ncbi.nlm.nih.gov/pubmed/36015221 http://dx.doi.org/10.3390/pharmaceutics14081595

Ejemplares similares

Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
por: Brembati, Viviana, et al.
Publicado: (2023)

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease
por: Brembati, Viviana, et al.
Publicado: (2023)

Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ
por: Casiraghi, Andrea, et al.
Publicado: (2020)

Study of alpha-synuclein fibrillation: state of the art and expectations
por: Longhena, Francesca, et al.
Publicado: (2019)

The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy
por: Longhena, Francesca, et al.
Publicado: (2017)

Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
por: Longhena, Francesca, et al.
Publicado: (2019)

Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson’s Disease: An In Situ Proximity Ligation Assay Study
por: Longhena, Francesca, et al.
Publicado: (2018)

Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease
por: Bellucci, Arianna, et al.
Publicado: (2020)

Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells
por: Faustini, Gaia, et al.
Publicado: (2019)

Resolution via diastereomeric amides of enantiopure 1,4‐benzoxathian‐2‐ and 3‐carboxylic acids and determination of their configuration
por: Straniero, Valentina, et al.
Publicado: (2022)

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives
por: Bogale, Tizibt Ashine, et al.
Publicado: (2021)

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
por: Faustini, Gaia, et al.
Publicado: (2017)

Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype
por: Faustini, Gaia, et al.
Publicado: (2022)

Computational Design and Development of Benzodioxane-Benzamides as Potent Inhibitors of FtsZ by Exploring the Hydrophobic Subpocket
por: Straniero, Valentina, et al.
Publicado: (2021)

Staphylococcus aureus RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation
por: Suigo, Lorenzo, et al.
Publicado: (2021)

Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity
por: Straniero, Valentina, et al.
Publicado: (2020)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
por: Zaltieri, Michela, et al.
Publicado: (2015)

Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
por: Filippini, Alice, et al.
Publicado: (2020)

NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice
por: Parrella, Edoardo, et al.
Publicado: (2019)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

The Role of Rab Proteins in Parkinson’s Disease Synaptopathy
por: Bellucci, Arianna, et al.
Publicado: (2022)

The Association between α-Synuclein and α-Tubulin in Brain Synapses
por: Amadeo, Alida, et al.
Publicado: (2021)

Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates
por: Faustini, Gaia, et al.
Publicado: (2022)

Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction
por: Ponterio, Giulia, et al.
Publicado: (2022)

DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease
por: Masato, Anna, et al.
Publicado: (2023)

Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease
por: Bellucci, Arianna, et al.
Publicado: (2011)

Correction: Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease
por: Bellucci, Arianna, et al.
Publicado: (2012)

Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson’s disease
por: Pike, Adrianne F., et al.
Publicado: (2022)

An Updated Overview on the Role of Small Molecules and Natural Compounds in the “Young Science” of Rejuvenation
por: Ribaudo, Giovanni, et al.
Publicado: (2023)

Functionalization of Piperidine Derivatives for the Site‐Selective and Stereoselective Synthesis of Positional Analogues of Methylphenidate
por: Liu, Wenbin, et al.
Publicado: (2020)

Use of Methylphenidate Analogues as Cognitive Enhancers: The Prelude to Cosmetic Neurology and an Ethical Issue
por: Zaami, Simona, et al.
Publicado: (2020)

A Perspective on Natural and Nature-Inspired Small Molecules Targeting Phosphodiesterase 9 (PDE9): Chances and Challenges against Neurodegeneration
por: Ribaudo, Giovanni, et al.
Publicado: (2021)

Neurobiologic Rationale for Treatment of Apathy in Alzheimer’s Disease With Methylphenidate
por: van Dyck, Christopher H., et al.
Publicado: (2020)

Therapeutic Potential of Phosphodiesterase Inhibitors against Neurodegeneration: The Perspective of the Medicinal Chemist
por: Ribaudo, Giovanni, et al.
Publicado: (2020)

Combining Electrospray Mass Spectrometry (ESI-MS) and Computational Techniques in the Assessment of G-Quadruplex Ligands: A Hybrid Approach to Optimize Hit Discovery
por: Ribaudo, Giovanni, et al.
Publicado: (2021)

Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein–Protein Docking, Molecular Dynamics, and MM-GBSA Calculations
por: Ongaro, Alberto, et al.
Publicado: (2021)

Cannabidiol preferentially binds TRPV2: a novel mechanism of action
por: Landucci, Elisa, et al.
Publicado: (2022)

Methylphenidate-associated myopathy
por: Vargas, Ana Beatriz, et al.
Publicado: (2012)

The cardiovascular safety of methylphenidate
por: Jackson, John W
Publicado: (2016)

Editorial: Attention and Methylphenidate
por: Avital, Avi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0h3jsi2flpbvfsj09ciocr992t