Adapting Simon’s Two-Stage Design for Efficient Screening of Filovirus Vaccines in Non-Human Primates

The cynomolgus monkey (Macaca fascicularis) non-human primate (NHP) is widely used for filovirus vaccine testing. To use limited BSL-4 resources efficiently and minimize NHP usage, Simon’s two-stage design was adapted to screen candidate Ebola virus (EBOV) vaccines in up to six NHPs with two (optima...

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Detalles Bibliográficos
Autores principales: Niemuth, Nancy A., Sabourin, Carol L., Ward, Lucy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414402/
https://www.ncbi.nlm.nih.gov/pubmed/36016104
http://dx.doi.org/10.3390/vaccines10081216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414402/
https://www.ncbi.nlm.nih.gov/pubmed/36016104
http://dx.doi.org/10.3390/vaccines10081216

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