Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) via EGFR/PI3K/AKT/mTOR Signaling Cascades

Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazi...

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Detalles Bibliográficos
Autores principales: Shawish, Ihab, Barakat, Assem, Aldalbahi, Ali, Alshaer, Walhan, Daoud, Fadwa, Alqudah, Dana A., Al Zoubi, Mazhar, Hatmal, Ma’mon M., Nafie, Mohamed S., Haukka, Matti, Sharma, Anamika, de la Torre, Beatriz G., Albericio, Fernando, El-Faham, Ayman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414415/
https://www.ncbi.nlm.nih.gov/pubmed/36015186
http://dx.doi.org/10.3390/pharmaceutics14081558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414415/
https://www.ncbi.nlm.nih.gov/pubmed/36015186
http://dx.doi.org/10.3390/pharmaceutics14081558

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