Cargando…

Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases

BET proteins, which recognize and bind to acetylated histones, play a key role in transcriptional regulation. The development of chemical BET inhibitors in 2010 greatly facilitated the study of these proteins. BETs play crucial roles in cancer, inflammation, heart failure, and fibrosis. In particula...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Dayu, Duan, Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414451/
https://www.ncbi.nlm.nih.gov/pubmed/36015180
http://dx.doi.org/10.3390/ph15081032
_version_ 1784775990772236288
author Wu, Dayu
Duan, Qiong
author_facet Wu, Dayu
Duan, Qiong
author_sort Wu, Dayu
collection PubMed
description BET proteins, which recognize and bind to acetylated histones, play a key role in transcriptional regulation. The development of chemical BET inhibitors in 2010 greatly facilitated the study of these proteins. BETs play crucial roles in cancer, inflammation, heart failure, and fibrosis. In particular, BETs may be involved in regulating metabolic processes, such as adipogenesis and metaflammation, which are under tight transcriptional regulation. In addition, acetyl-CoA links energy metabolism with epigenetic modification through lysine acetylation, which creates docking sites for BET. Given this, it is possible that the ambient energy status may dictate metabolic gene transcription via a BET-dependent mechanism. Indeed, recent studies have reported that various BET proteins are involved in both metabolic signaling regulation and disease. Here, we discuss some of the most recent information on BET proteins and their regulation of the metabolism in both cellular and animal models. Further, we summarize data from some randomized clinical trials evaluating BET inhibitors for the treatment of metabolic diseases.
format Online
Article
Text
id pubmed-9414451
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94144512022-08-27 Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases Wu, Dayu Duan, Qiong Pharmaceuticals (Basel) Review BET proteins, which recognize and bind to acetylated histones, play a key role in transcriptional regulation. The development of chemical BET inhibitors in 2010 greatly facilitated the study of these proteins. BETs play crucial roles in cancer, inflammation, heart failure, and fibrosis. In particular, BETs may be involved in regulating metabolic processes, such as adipogenesis and metaflammation, which are under tight transcriptional regulation. In addition, acetyl-CoA links energy metabolism with epigenetic modification through lysine acetylation, which creates docking sites for BET. Given this, it is possible that the ambient energy status may dictate metabolic gene transcription via a BET-dependent mechanism. Indeed, recent studies have reported that various BET proteins are involved in both metabolic signaling regulation and disease. Here, we discuss some of the most recent information on BET proteins and their regulation of the metabolism in both cellular and animal models. Further, we summarize data from some randomized clinical trials evaluating BET inhibitors for the treatment of metabolic diseases. MDPI 2022-08-22 /pmc/articles/PMC9414451/ /pubmed/36015180 http://dx.doi.org/10.3390/ph15081032 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Dayu
Duan, Qiong
Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
title Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
title_full Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
title_fullStr Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
title_full_unstemmed Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
title_short Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
title_sort roles of bromodomain extra terminal proteins in metabolic signaling and diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414451/
https://www.ncbi.nlm.nih.gov/pubmed/36015180
http://dx.doi.org/10.3390/ph15081032
work_keys_str_mv AT wudayu rolesofbromodomainextraterminalproteinsinmetabolicsignalinganddiseases
AT duanqiong rolesofbromodomainextraterminalproteinsinmetabolicsignalinganddiseases