The 46.1 Antibody Mediates Neurotensin Uptake into the CNS and the Effects Depend on the Route of Intravenous Administration

Central nervous system (CNS) exposure to blood-borne biotherapeutics is limited by the restrictive nature of the brain vasculature. In particular, tightly sealed endothelial cells of the blood–brain barrier (BBB) prevent the uptake of protein and gene medicines. An approach to increase the bioavaila...

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Detalles Bibliográficos
Autores principales: Georgieva, Julia V., Katt, Moriah, Ye, Zhou, Umlauf, Benjamin J., Wenthur, Cody J., Shusta, Eric V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414616/
https://www.ncbi.nlm.nih.gov/pubmed/36015332
http://dx.doi.org/10.3390/pharmaceutics14081706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414616/
https://www.ncbi.nlm.nih.gov/pubmed/36015332
http://dx.doi.org/10.3390/pharmaceutics14081706

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