Enhanced Ocular Anti-Aspergillus Activity of Tolnaftate Employing Novel Cosolvent-Modified Spanlastics: Formulation, Statistical Optimization, Kill Kinetics, Ex Vivo Trans-Corneal Permeation, In Vivo Histopathological and Susceptibility Study

Tolnaftate (TOL) is a thiocarbamate fungicidal drug used topically in the form of creams and ointments. No ocular formulations of TOL are available for fungal keratitis (FK) treatment due to its poor water solubility and unique ocular barriers. Therefore, this study aimed at developing novel modifie...

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Detalles Bibliográficos
Autores principales: Aziz, Diana, Mohamed, Sally A., Tayel, Saadia, Makhlouf, Amal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415006/
https://www.ncbi.nlm.nih.gov/pubmed/36015372
http://dx.doi.org/10.3390/pharmaceutics14081746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415006/
https://www.ncbi.nlm.nih.gov/pubmed/36015372
http://dx.doi.org/10.3390/pharmaceutics14081746

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