Evidence of Isomerization in the Michael-Type Thiol-Maleimide Addition: Click Reaction between L-Cysteine and 6-Maleimidehexanoic Acid

The reaction between L-cysteine (Cys) and 6-maleimidohexanoic acid (Mhx) in an aqueous medium at different levels of pH was analyzed via RP-HPLC, finding the presence of two reaction products throughout the evaluated pH range. By means of solid-phase extraction (SPE), it was possible to separate the...

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Detalles Bibliográficos
Autores principales: Niño-Ramírez, Víctor Alfonso, Insuasty-Cepeda, Diego Sebastián, Rivera-Monroy, Zuly Jenny, Maldonado, Mauricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415311/
https://www.ncbi.nlm.nih.gov/pubmed/36014302
http://dx.doi.org/10.3390/molecules27165064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415311/
https://www.ncbi.nlm.nih.gov/pubmed/36014302
http://dx.doi.org/10.3390/molecules27165064

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