Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities

A further investigation aiming to generate new potential antitumor agents led us to synthesize a new series of twenty-two compounds characterized by the presence of the 7-(3′,4′,5′-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine pharmacophore modified at its 2-position. Among the synthesized comp...

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Detalles Bibliográficos
Autores principales: Romagnoli, Romeo, Oliva, Paola, Prencipe, Filippo, Manfredini, Stefano, Budassi, Federica, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Corallo, Diana, Aveic, Sanja, Manfreda, Lorenzo, Mariotto, Elena, Bortolozzi, Roberta, Viola, Giampietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415608/
https://www.ncbi.nlm.nih.gov/pubmed/36015179
http://dx.doi.org/10.3390/ph15081031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415608/
https://www.ncbi.nlm.nih.gov/pubmed/36015179
http://dx.doi.org/10.3390/ph15081031

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