Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

New series of thiazolyl-pyrazoline derivatives (7a–7d, 10a–10d and 13a–13f) have been synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities. Compounds 10b and 10d exerted potent and selective inhibitory activity towards the two receptor tyrosine kinases; EGFR (IC(50) =...

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Detalles Bibliográficos
Autores principales: Abdelsalam, Esraa A., Abd El-Hafeez, Amer Ali, Eldehna, Wagdy M., El Hassab, Mahmoud A., Marzouk, Hala Mohamed M., Elaasser, Mahmoud M., Abou Taleb, Nageh A., Amin, Kamilia M., Abdel-Aziz, Hatem A., Ghosh, Pradipta, Hammad, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415638/
https://www.ncbi.nlm.nih.gov/pubmed/36000167
http://dx.doi.org/10.1080/14756366.2022.2104841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415638/
https://www.ncbi.nlm.nih.gov/pubmed/36000167
http://dx.doi.org/10.1080/14756366.2022.2104841

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