Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore

An antileishmanial structure–activity relationship (SAR) study focused on positions 2 and 8 of the imidazo[1,2-a]pyridine ring was conducted through the synthesis of 22 new derivatives. After being screened on the promatigote and axenic amastigote stages of Leishmania donovani and L. infantum, the b...

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Detalles Bibliográficos
Autores principales: Paoli-Lombardo, Romain, Primas, Nicolas, Bourgeade-Delmas, Sandra, Hutter, Sébastien, Sournia-Saquet, Alix, Boudot, Clotilde, Brenot, Emilie, Castera-Ducros, Caroline, Corvaisier, Sophie, Since, Marc, Malzert-Fréon, Aurélie, Courtioux, Bertrand, Valentin, Alexis, Verhaeghe, Pierre, Azas, Nadine, Rathelot, Pascal, Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415646/
https://www.ncbi.nlm.nih.gov/pubmed/36015146
http://dx.doi.org/10.3390/ph15080998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415646/
https://www.ncbi.nlm.nih.gov/pubmed/36015146
http://dx.doi.org/10.3390/ph15080998

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