SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

The on-going global pandemic of COVID-19 is caused by SARS-CoV-2, which features a proofreading mechanism to facilitate the replication of its large RNA genome. The 3′-to-5′ exoribonuclease (ExoN) activity of SARS-CoV-2 non-structural protein 14 (nsp14) removes nucleotides misincorporated during RNA...

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Detalles Bibliográficos
Autores principales: Moeller, Nicholas H., Passow, Kellan T., Harki, Daniel A., Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415739/
https://www.ncbi.nlm.nih.gov/pubmed/36016411
http://dx.doi.org/10.3390/v14081790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415739/
https://www.ncbi.nlm.nih.gov/pubmed/36016411
http://dx.doi.org/10.3390/v14081790

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