Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection

Coagulation factor Xa (fXa) and thrombin (thr) are widely expressed in pulmonary tissues, where they may catalyze, together with the transmembrane serine protease 2 (TMPRSS2), the coronaviruses spike protein (SP) cleavage and activation, thus enhancing the SP binding to ACE2 and cell infection. In t...

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Detalles Bibliográficos
Autores principales: De Maio, Flavio, Rullo, Mariagrazia, de Candia, Modesto, Purgatorio, Rosa, Lopopolo, Gianfranco, Santarelli, Giulia, Palmieri, Valentina, Papi, Massimiliano, Elia, Gabriella, De Candia, Erica, Sanguinetti, Maurizio, Altomare, Cosimo Damiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415951/
https://www.ncbi.nlm.nih.gov/pubmed/36016352
http://dx.doi.org/10.3390/v14081730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415951/
https://www.ncbi.nlm.nih.gov/pubmed/36016352
http://dx.doi.org/10.3390/v14081730

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