Cargando…

Development and In Vitro-Ex Vivo Evaluation of Novel Polymeric Nasal Donepezil Films for Potential Use in Alzheimer’s Disease Using Experimental Design

The objective and novelty of the present study is the development and optimization of innovative nasal film of Donepezil hydrochloride (DH) for potential use in Alzheimer’s disease. Hydroxypropyl-methyl-cellulose E50 (factor A) nasal films, with Polyethylene glycol 400 as plasticizer (factor B), and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Papakyriakopoulou, Paraskevi, Rekkas, Dimitrios M., Colombo, Gaia, Valsami, Georgia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416078/ https://www.ncbi.nlm.nih.gov/pubmed/36015368 http://dx.doi.org/10.3390/pharmaceutics14081742

Ejemplares similares

Donepezil Brain and Blood Pharmacokinetic Modeling after Nasal Film and Oral Solution Administration in Mice
por: Kaikousidis, Christos, et al.
Publicado: (2023)

Design of a Personalized Nasal Device (Matrix-Piston Nasal Device, MPD) for Drug Delivery: a 3D-Printing Application
por: Menegatou, Ioanna-Maria, et al.
Publicado: (2022)

Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles
por: Manta, Konstantina, et al.
Publicado: (2023)

Advances in intranasal vaccine delivery: A promising non-invasive route of immunization
por: Kehagia, Eleni, et al.
Publicado: (2023)

Development and Pharmacokinetics of a Novel Acetylsalicylic Acid Dry Powder for Pulmonary Administration
por: Pacławski, Adam, et al.
Publicado: (2022)

Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease
por: Al Harthi, Sitah, et al.
Publicado: (2019)

Potential Pharmaceutical Applications of Quercetin in Cardiovascular Diseases
por: Papakyriakopoulou, Paraskevi, et al.
Publicado: (2022)

Bio-Actives from Natural Products with Potential Cardioprotective Properties: Isolation, Identification, and Pharmacological Actions of Apigenin, Quercetin, and Silibinin
por: Tomou, Ekaterina-Michaela, et al.
Publicado: (2023)

Recent Advances in Nanoformulations for Quercetin Delivery
por: Tomou, Ekaterina-Michaela, et al.
Publicado: (2023)

Comparative Study of Donepezil-Loaded Formulations for the Treatment of Alzheimer’s Disease by Nasal Administration
por: Espinoza, Lupe Carolina, et al.
Publicado: (2022)

Transdermal donepezil on the treatment of Alzheimer’s disease
por: Sozio, Piera, et al.
Publicado: (2012)

Donepezil Beyond Alzheimer's Disease? A Narrative Review of Therapeutic Potentials of Donepezil in Different Diseases
por: Pooladgar, Parham, et al.
Publicado: (2022)

Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration
por: Kikionis, Stefanos, et al.
Publicado: (2023)

Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics
por: Cacabelos, Ramón
Publicado: (2007)

Donepezil enhances understanding of degraded speech in Alzheimer's disease
por: Hardy, Chris J. D., et al.
Publicado: (2017)

Donepezil Treatment for Alzheimer's Disease in Chronic Dialysis Patients
por: Yiannopoulou, Konstantina G., et al.
Publicado: (2019)

Comparative Interaction Studies of Quercetin with 2-Hydroxyl-propyl-β-cyclodextrin and 2,6-Methylated-β-cyclodextrin
por: Vakali, Vasiliki, et al.
Publicado: (2022)

Use of Methylphenidate in Excessive Daytime Sleepiness in Alzheimer’s Patients Treated with Donepezil: Case Series
por: Bidzan, Leszek, et al.
Publicado: (2020)

Studies on Interaction of Buffalo Brain Cystatin with Donepezil: An Alzheimer's Drug
por: Amin, Fakhra, et al.
Publicado: (2013)

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
por: Unzeta, Mercedes, et al.
Publicado: (2016)

Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease
por: Hwang, Yun Tae, et al.
Publicado: (2018)

Commentary: Donepezil enhances understanding of degraded speech in Alzheimer's disease
por: Campbell, Tom A., et al.
Publicado: (2018)

Donepezil Plus Solifenacin (CPC-201) Treatment for Alzheimer’s Disease
por: Chase, Thomas N., et al.
Publicado: (2017)

Evaluating the cost effectiveness of donepezil in the treatment of Alzheimer's disease in Germany using discrete event simulation
por: Hartz, Susanne, et al.
Publicado: (2012)

Ex Vivo Conjunctival Retention and Transconjunctival Transport of Poorly Soluble Drugs Using Polymeric Micelles
por: Pescina, Silvia, et al.
Publicado: (2019)

Development of a Novel Apigenin Dosage form as a Substitute for the Modern Triple Antithrombotic Regimen
por: Tsiailanis, Antonios D., et al.
Publicado: (2023)

Ex-Vivo and In-Vivo Assessment of Cyclamen europaeum Extract After Nasal Administration
por: Fernández-Campos, Francisco, et al.
Publicado: (2019)

Clinical Recommendations for the Use of Donepezil 23 mg in Moderate-to-Severe Alzheimer's Disease in the Asia-Pacific Region
por: Sabbagh, Marwan, et al.
Publicado: (2016)

Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease
por: Farlow, Martin, et al.
Publicado: (2011)

Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients
por: Zhang, Nan, et al.
Publicado: (2018)

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
por: Pachón-Angona, Irene, et al.
Publicado: (2019)

Donepezil improves vascular function in a mouse model of Alzheimer’s disease
por: Pellegrini, Carolina, et al.
Publicado: (2021)

Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia
por: Park, Kee Hyung, et al.
Publicado: (2021)

Donepezil plus memantine versus donepezil alone for treatment of concomitant Alzheimer’s disease and chronic obstructive pulmonary disease: a retrospective observational study
por: Cao, Yangyi, et al.
Publicado: (2020)

A donepezil/cyclodextrin complexation orodispersible film: Effect of cyclodextrin on taste-masking based on dynamic process and in vivo drug absorption
por: Liu, Tingting, et al.
Publicado: (2019)

Prediction of Treatment Response to Donepezil using Automated Hippocampal Subfields Volumes Segmentation in Patients with Mild Alzheimer's Disease
por: Um, Yoo Hyun, et al.
Publicado: (2017)

Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil
por: Al Asmari, Abdulrahman K, et al.
Publicado: (2016)

Delirium Associated with Donepezil in a Patient with Alzheimer's Disease: a Case Report
por: Mollazadeh-Moghaddam, Kamyar, et al.
Publicado: (2013)

Donepezil and life expectancy in Alzheimer’s disease: A retrospective analysis in the Tajiri Project
por: Meguro, Kenichi, et al.
Publicado: (2014)

The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease
por: Lee, Kang Uk, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_74abik2nrjp6svcs0i622q9urf