Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease

Variants in the GBA1 and LRRK2 genes are the most common genetic risk factors associated with Parkinson disease (PD). Both genes are associated with lysosomal and autophagic pathways, with the GBA1 gene encoding for the lysosomal enzyme, glucocerebrosidase (GCase) and the LRRK2 gene encoding for the...

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Detalles Bibliográficos
Autores principales: Smith, Laura J., Lee, Chiao-Yin, Menozzi, Elisa, Schapira, Anthony H. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416236/
https://www.ncbi.nlm.nih.gov/pubmed/36034282
http://dx.doi.org/10.3389/fneur.2022.971252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416236/
https://www.ncbi.nlm.nih.gov/pubmed/36034282
http://dx.doi.org/10.3389/fneur.2022.971252

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