Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome

A new class of alkynyl isoquinoline antibacterial compounds, synthesized via Sonogashira coupling, with strong bactericidal activity against a plethora of Gram-positive bacteria including methicillin- and vancomycin-resistant Staphylococcus aureus (S. aureus) strains is presented. HSN584 and HSN739,...

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Detalles Bibliográficos
Autores principales: Karanja, Caroline W., Naganna, Nimishetti, Abutaleb, Nader S., Dayal, Neetu, Onyedibe, Kenneth I., Aryal, Uma, Seleem, Mohamed N., Sintim, Herman O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416421/
https://www.ncbi.nlm.nih.gov/pubmed/36014324
http://dx.doi.org/10.3390/molecules27165085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416421/
https://www.ncbi.nlm.nih.gov/pubmed/36014324
http://dx.doi.org/10.3390/molecules27165085

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