Continuous-Flow Synthesis of Nitro-o-xylenes: Process Optimization, Impurity Study and Extension to Analogues

An efficient continuous-flow nitration process of o-xylene at pilot scale was demonstrated. The effects of parameters such as temperature, ratio of H(2)SO(4) to HNO(3), H(2)SO(4) concentration, flow rate, and residence time on the reaction were studied. Under the optimal conditions, the yield of pro...

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Detalles Bibliográficos
Autores principales: Song, Qiao, Lei, Xiangui, Yang, Sheng, Wang, Sheng, Wang, Jianhui, Chen, Jiujun, Xiang, Yong, Huang, Qingwu, Wang, Zhouyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416712/
https://www.ncbi.nlm.nih.gov/pubmed/36014379
http://dx.doi.org/10.3390/molecules27165139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416712/
https://www.ncbi.nlm.nih.gov/pubmed/36014379
http://dx.doi.org/10.3390/molecules27165139

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