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Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model
Tremendous progress has been made in the field of nanomedicine for cancer treatment. However, most of the research to date has been focused on inhibiting primary tumor growth with comparatively less efforts directed towards managing tumor metastasis. Here, we introduce a polymeric conjugate P-DOX-iR...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416753/ https://www.ncbi.nlm.nih.gov/pubmed/36015351 http://dx.doi.org/10.3390/pharmaceutics14081725 |
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author | Peng, Zheng-Hong Jogdeo, Chinmay M. Li, Jing Xie, Ying Wang, Yazhe Sheinin, Yuri M. Kopeček, Jindřich Oupický, David |
author_facet | Peng, Zheng-Hong Jogdeo, Chinmay M. Li, Jing Xie, Ying Wang, Yazhe Sheinin, Yuri M. Kopeček, Jindřich Oupický, David |
author_sort | Peng, Zheng-Hong |
collection | PubMed |
description | Tremendous progress has been made in the field of nanomedicine for cancer treatment. However, most of the research to date has been focused on inhibiting primary tumor growth with comparatively less efforts directed towards managing tumor metastasis. Here, we introduce a polymeric conjugate P-DOX-iRGD that not only significantly suppressed primary tumor growth but also substantially inhibited pulmonary metastasis in an orthotopic mouse model of breast cancer. In addition, treatment with P-DOX-iRGD markedly reduced breast cancer-induced splenomegaly and liver hematopoiesis. Interestingly, contrasting results were seen for the free form and polymeric form of DOX in vitro and in vivo, which may be attributed to the enhanced permeability and retention (EPR) effect. |
format | Online Article Text |
id | pubmed-9416753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94167532022-08-27 Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model Peng, Zheng-Hong Jogdeo, Chinmay M. Li, Jing Xie, Ying Wang, Yazhe Sheinin, Yuri M. Kopeček, Jindřich Oupický, David Pharmaceutics Article Tremendous progress has been made in the field of nanomedicine for cancer treatment. However, most of the research to date has been focused on inhibiting primary tumor growth with comparatively less efforts directed towards managing tumor metastasis. Here, we introduce a polymeric conjugate P-DOX-iRGD that not only significantly suppressed primary tumor growth but also substantially inhibited pulmonary metastasis in an orthotopic mouse model of breast cancer. In addition, treatment with P-DOX-iRGD markedly reduced breast cancer-induced splenomegaly and liver hematopoiesis. Interestingly, contrasting results were seen for the free form and polymeric form of DOX in vitro and in vivo, which may be attributed to the enhanced permeability and retention (EPR) effect. MDPI 2022-08-18 /pmc/articles/PMC9416753/ /pubmed/36015351 http://dx.doi.org/10.3390/pharmaceutics14081725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Peng, Zheng-Hong Jogdeo, Chinmay M. Li, Jing Xie, Ying Wang, Yazhe Sheinin, Yuri M. Kopeček, Jindřich Oupický, David Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model |
title | Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model |
title_full | Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model |
title_fullStr | Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model |
title_full_unstemmed | Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model |
title_short | Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model |
title_sort | tumor microenvironment-responsive polymeric irgd and doxorubicin conjugates reduce spontaneous lung metastasis in an orthotopic breast cancer model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416753/ https://www.ncbi.nlm.nih.gov/pubmed/36015351 http://dx.doi.org/10.3390/pharmaceutics14081725 |
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