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Opioids alter paw placement during walking, confounding assessment of analgesic efficacy in a postsurgical pain model in mice
INTRODUCTION: Hind paw–directed assays are commonly used to study the analgesic effects of opioids in mice. However, opioid-induced hyperlocomotion can obscure results of such assays. OBJECTIVES: We aimed to overcome this potential confound by using gait analysis to observe hind paw usage during wal...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wolters Kluwer
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416758/ https://www.ncbi.nlm.nih.gov/pubmed/36034600 http://dx.doi.org/10.1097/PR9.0000000000001035 |