Selective One-Pot Multicomponent Synthesis of N-Substituted 2,3,5-Functionalized 3-Cyanopyrroles via the Reaction between α-Hydroxyketones, Oxoacetonitriles, and Primary Amines

A one-step, three-component reaction between α-hydroxyketones, oxoacetonitriles, and primary amines gives N-substituted 2,3,5-functionalized 3-cyanopyrroles with complete selectivity in up to 90% isolated yields. The reaction worked on a wide substrate scope under mild reaction conditions (AcOH as a...

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Detalles Bibliográficos
Autores principales: Xia, Mengxin, Moussa, Ziad, Judeh, Zaher M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416797/
https://www.ncbi.nlm.nih.gov/pubmed/36014523
http://dx.doi.org/10.3390/molecules27165285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416797/
https://www.ncbi.nlm.nih.gov/pubmed/36014523
http://dx.doi.org/10.3390/molecules27165285

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