S146L in MYC is a context-dependent activating substitution in cancer development

MYC is one of the most dysregulated oncogenes and is thought to be fundamental to tumor formation and/or maintenance in many cancer types. This dominant pro-tumor activity makes MYC an attractive target for cancer therapy. However, MYC is a transcription factor lacking enzymatic activity, and the st...

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Detalles Bibliográficos
Autores principales: Hinds, John W., Feris, Edmond J., Wilkins, Owen M., Deary, Luke T., Wang, Xiaofeng, Cole, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417018/
https://www.ncbi.nlm.nih.gov/pubmed/36018850
http://dx.doi.org/10.1371/journal.pone.0272771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417018/
https://www.ncbi.nlm.nih.gov/pubmed/36018850
http://dx.doi.org/10.1371/journal.pone.0272771

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