Cancer-driving mutations are enriched in genic regions intolerant to germline variation

Large reference datasets of protein-coding variation in human populations have allowed us to determine which genes and genic subregions are intolerant to germline genetic variation. There is also a growing number of genes implicated in severe Mendelian diseases that overlap with genes implicated in...

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Detalles Bibliográficos
Autores principales: Vitsios, Dimitrios, Dhindsa, Ryan S., Matelska, Dorota, Mitchell, Jonathan, Zou, Xuequing, Armenia, Joshua, Hu, Fengyuan, Wang, Quanli, Sidders, Ben, Harper, Andrew R., Petrovski, Slavé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417173/
https://www.ncbi.nlm.nih.gov/pubmed/36026442
http://dx.doi.org/10.1126/sciadv.abo6371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417173/
https://www.ncbi.nlm.nih.gov/pubmed/36026442
http://dx.doi.org/10.1126/sciadv.abo6371

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