Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice

Articular cartilage has low regenerative capacity despite permanent stress. Irreversible cartilage lesions characterize osteoarthritis (OA); this is not followed by tissue repair. Lin28a, an RNA binding protein, is detected in damaged cartilage in humans and mice. We investigated the role of LIN28a...

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Detalles Bibliográficos
Autores principales: Jouan, Yohan, Bouchemla, Zohra, Bardèche-Trystram, Benoit, Sana, Joanna, Andrique, Caroline, Ea, Hang-Korng, Richette, Pascal, Latourte, Augustin, Cohen-Solal, Martine, Hay, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417174/
https://www.ncbi.nlm.nih.gov/pubmed/36026443
http://dx.doi.org/10.1126/sciadv.abn3106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417174/
https://www.ncbi.nlm.nih.gov/pubmed/36026443
http://dx.doi.org/10.1126/sciadv.abn3106

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