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Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice
Articular cartilage has low regenerative capacity despite permanent stress. Irreversible cartilage lesions characterize osteoarthritis (OA); this is not followed by tissue repair. Lin28a, an RNA binding protein, is detected in damaged cartilage in humans and mice. We investigated the role of LIN28a...
Autores principales: | Jouan, Yohan, Bouchemla, Zohra, Bardèche-Trystram, Benoit, Sana, Joanna, Andrique, Caroline, Ea, Hang-Korng, Richette, Pascal, Latourte, Augustin, Cohen-Solal, Martine, Hay, Eric |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417174/ https://www.ncbi.nlm.nih.gov/pubmed/36026443 http://dx.doi.org/10.1126/sciadv.abn3106 |
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