PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons

How neurons can maintain cellular identity over an entire life span remains largely unknown. Here, we show that maintenance of identity in differentiated dopaminergic and serotonergic neurons is critically reliant on the Polycomb repressive complex 2 (PRC2). Deletion of the obligate PRC2 component,...

Descripción completa

Detalles Bibliográficos
Autores principales: Toskas, Konstantinos, Yaghmaeian-Salmani, Behzad, Skiteva, Olga, Paslawski, Wojciech, Gillberg, Linda, Skara, Vasiliki, Antoniou, Irene, Södersten, Erik, Svenningsson, Per, Chergui, Karima, Ringnér, Markus, Perlmann, Thomas, Holmberg, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417181/
https://www.ncbi.nlm.nih.gov/pubmed/36026451
http://dx.doi.org/10.1126/sciadv.abo1543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417181/
https://www.ncbi.nlm.nih.gov/pubmed/36026451
http://dx.doi.org/10.1126/sciadv.abo1543

Ejemplares similares