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PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons
How neurons can maintain cellular identity over an entire life span remains largely unknown. Here, we show that maintenance of identity in differentiated dopaminergic and serotonergic neurons is critically reliant on the Polycomb repressive complex 2 (PRC2). Deletion of the obligate PRC2 component,...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417181/ https://www.ncbi.nlm.nih.gov/pubmed/36026451 http://dx.doi.org/10.1126/sciadv.abo1543 |