Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis

Aging is a risk factor for the development of osteoarthritis (OA), a progressive joint disease leading to cartilage damage, pain, and loss of function. In a mouse model of OA, senolytic drugs to selectively clear senescent cells (SnCs) that accumulate with injury or aging yielded a chondroprotective...

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Detalles Bibliográficos
Autores principales: Gil, Tae-Hwan, Zheng, Haiyan, Lee, Hyo Gyeong, Shin, Ji-Won, Hwang, Sun Wook, Jang, Ki-Mo, Jeon, Ok Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417227/
https://www.ncbi.nlm.nih.gov/pubmed/35951358
http://dx.doi.org/10.18632/aging.204204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417227/
https://www.ncbi.nlm.nih.gov/pubmed/35951358
http://dx.doi.org/10.18632/aging.204204

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