Autophagy Induction via STING Trafficking Is a Primordial Function of the cGAS Pathway

Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm(1). Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK and TBK1 to induce interferons and oth...

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Detalles Bibliográficos
Autores principales: Gui, Xiang, Yang, Hui, Li, Tuo, Tan, Xiaojun, Shi, Peiqing, Li, Minghao, Du, Fenghe, Chen, Zhijian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417302/
https://www.ncbi.nlm.nih.gov/pubmed/30842662
http://dx.doi.org/10.1038/s41586-019-1006-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417302/
https://www.ncbi.nlm.nih.gov/pubmed/30842662
http://dx.doi.org/10.1038/s41586-019-1006-9

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