Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing

Lipid nanoparticles (LNPs) are gaining traction in the field of nucleic acid delivery following the success of two mRNA vaccines against COVID-19. As one of the constituent lipids on LNP surfaces, PEGylated lipids (PEG-lipids) play an important role in defining LNP physicochemical properties and bio...

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Detalles Bibliográficos
Autores principales: Sarode, Apoorva, Fan, Yuchen, Byrnes, Amy E., Hammel, Michal, Hura, Greg L., Fu, Yige, Kou, Ponien, Hu, Chloe, Hinz, Flora I., Roberts, Jasmine, Koenig, Stefan G., Nagapudi, Karthik, Hoogenraad, Casper C., Chen, Tao, Leung, Dennis, Yen, Chun-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417559/
https://www.ncbi.nlm.nih.gov/pubmed/36133441
http://dx.doi.org/10.1039/d1na00712b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417559/
https://www.ncbi.nlm.nih.gov/pubmed/36133441
http://dx.doi.org/10.1039/d1na00712b

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