Cargando…

Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing

Lipid nanoparticles (LNPs) are gaining traction in the field of nucleic acid delivery following the success of two mRNA vaccines against COVID-19. As one of the constituent lipids on LNP surfaces, PEGylated lipids (PEG-lipids) play an important role in defining LNP physicochemical properties and bio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarode, Apoorva, Fan, Yuchen, Byrnes, Amy E., Hammel, Michal, Hura, Greg L., Fu, Yige, Kou, Ponien, Hu, Chloe, Hinz, Flora I., Roberts, Jasmine, Koenig, Stefan G., Nagapudi, Karthik, Hoogenraad, Casper C., Chen, Tao, Leung, Dennis, Yen, Chun-Wan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417559/ https://www.ncbi.nlm.nih.gov/pubmed/36133441 http://dx.doi.org/10.1039/d1na00712b

Ejemplares similares

Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering
por: Hammel, Michal, et al.
Publicado: (2023)

Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection
por: Byrnes, Amy E., et al.
Publicado: (2023)

CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids
por: Park, Soohyung, et al.
Publicado: (2021)

Lipid–oligonucleotide conjugates for bioapplications
por: Li, Xiaowei, et al.
Publicado: (2020)

Thermotropic effects of PEGylated lipids on the stability of HPPH-encapsulated lipid nanoparticles (LNP)
por: Kalyanram, Poornima, et al.
Publicado: (2021)

Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer
por: Campani, Virginia, et al.
Publicado: (2016)

PEGylated Lipid Nanoparticle Formulations: Immunological Safety and Efficiency Perspective
por: Tenchov, Rumiana, et al.
Publicado: (2023)

Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome
por: Tran, Phuc, et al.
Publicado: (2022)

Lipid membrane interactions of self-assembling antimicrobial nanofibers: effect of PEGylation
por: Nielsen, Josefine Eilsø, et al.
Publicado: (2020)

A PEGylated Nanostructured Lipid Carrier for Enhanced Oral Delivery of Antibiotics
por: Alavi, Seyed Ebrahim, et al.
Publicado: (2022)

Silencing Antibiotic Resistance with Antisense Oligonucleotides
por: Jani, Saumya, et al.
Publicado: (2021)

Lipid oligonucleotides as a new strategy for tackling the antibiotic resistance
por: Kauss, Tina, et al.
Publicado: (2020)

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles
por: Bost, Jeremy P., et al.
Publicado: (2021)

Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material
por: Tanaka, Hiroki, et al.
Publicado: (2021)

Preparation and Characterization of Stealth Archaeosomes Based on a Synthetic PEGylated Archaeal Tetraether Lipid
por: Barbeau, Julie, et al.
Publicado: (2011)

Curcumin Containing PEGylated Solid Lipid Nanoparticles for Systemic Administration: A Preliminary Study
por: Santonocito, Debora, et al.
Publicado: (2020)

Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation
por: Angellotti, Giuseppe, et al.
Publicado: (2020)

Rationale and Application of PEGylated Lipid-Based System for Advanced Target Delivery of siRNA
por: Ge, Xuemei, et al.
Publicado: (2021)

Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing
por: Yamazoe, Sayumi, et al.
Publicado: (2014)

Nano and Microtechnologies for the Delivery of Oligonucleotides with Gene Silencing Properties
por: Rosa, Giuseppe De, et al.
Publicado: (2009)

Highly efficient silencing of microRNA by heteroduplex oligonucleotides
por: Yoshioka, Kotaro, et al.
Publicado: (2019)

Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides
por: Wang, Shiyu, et al.
Publicado: (2018)

Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo
por: Yang, Liu, et al.
Publicado: (2020)

Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages
por: Calero, Macarena, et al.
Publicado: (2022)

Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles
por: Zhao, Yongxue, et al.
Publicado: (2012)

Comparative Analysis of the Physicochemical and Biological Characteristics of Freeze-Dried PEGylated Cationic Solid Lipid Nanoparticles
por: Narváez-Narváez, David A., et al.
Publicado: (2023)

Tuning G-Quadruplex Nanostructures with Lipids. Towards Designing Hybrid Scaffolds for Oligonucleotide Delivery †
por: Grijalvo, Santiago, et al.
Publicado: (2020)

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing
por: Nishina, Kazutaka, et al.
Publicado: (2015)

Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing
por: Debart, Françoise, et al.
Publicado: (2018)

Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles
por: Zhang, Ling, et al.
Publicado: (2013)

Effects of PEGylated lipid nanoparticles on the oral absorption of one BCS II drug: a mechanistic investigation
por: Zhang, Xingwang, et al.
Publicado: (2014)

pH-sensitive PEGylation of RIPL peptide-conjugated nanostructured lipid carriers: design and in vitro evaluation
por: Kim, Chang Hyun, et al.
Publicado: (2018)

PEGylated aceclofenac solid lipid microparticles homolipid-based solidified reverse micellar solutions for drug delivery
por: Ugwu, Calister E., et al.
Publicado: (2022)

Microfluidic Post-Insertion Method for the Efficient Preparation of PEGylated Liposomes Using High Functionality and Quality Lipids
por: Sugimoto, Yuri, et al.
Publicado: (2022)

Influence of Surface-Modification via PEGylation or Chitosanization of Lipidic Nanocarriers on In Vivo Pharmacokinetic/Pharmacodynamic Profiles of Apixaban
por: Zaky, Mohamed F., et al.
Publicado: (2023)

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells
por: Basha, Genc, et al.
Publicado: (2011)

A Polyethylenimine-Containing and Transferrin-Conjugated Lipid Nanoparticle System for Antisense Oligonucleotide Delivery to AML
por: Yuan, Yiming, et al.
Publicado: (2016)

Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
por: Jin, Cheng, et al.
Publicado: (2019)

Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide
por: Yang, Shuang, et al.
Publicado: (2019)

Optimization of DOTAP/chol Cationic Lipid Nanoparticles for mRNA, pDNA, and Oligonucleotide Delivery
por: Sun, Mengwei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8s9h0idb452g6attq65ptadtrd