Cargando…
Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing
Lipid nanoparticles (LNPs) are gaining traction in the field of nucleic acid delivery following the success of two mRNA vaccines against COVID-19. As one of the constituent lipids on LNP surfaces, PEGylated lipids (PEG-lipids) play an important role in defining LNP physicochemical properties and bio...
Autores principales: | Sarode, Apoorva, Fan, Yuchen, Byrnes, Amy E., Hammel, Michal, Hura, Greg L., Fu, Yige, Kou, Ponien, Hu, Chloe, Hinz, Flora I., Roberts, Jasmine, Koenig, Stefan G., Nagapudi, Karthik, Hoogenraad, Casper C., Chen, Tao, Leung, Dennis, Yen, Chun-Wan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417559/ https://www.ncbi.nlm.nih.gov/pubmed/36133441 http://dx.doi.org/10.1039/d1na00712b |
Ejemplares similares
-
Correlating
the Structure and Gene Silencing Activity
of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray
Scattering
por: Hammel, Michal, et al.
Publicado: (2023) -
Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection
por: Byrnes, Amy E., et al.
Publicado: (2023) -
CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids
por: Park, Soohyung, et al.
Publicado: (2021) -
Lipid–oligonucleotide conjugates for bioapplications
por: Li, Xiaowei, et al.
Publicado: (2020) -
Thermotropic effects of PEGylated lipids on the stability of HPPH-encapsulated lipid nanoparticles (LNP)
por: Kalyanram, Poornima, et al.
Publicado: (2021)